Custom Peptides
Cayman Chemical GInsenosIde Rb2 10mg
A natural steroid glycoside with diverse effects; inhibits LPS-stimulated increases in VCAM-1 and ICAM-1 expression; reverses LPS-stimulated decreases in the expression of IκBα in HUVECs in a dose-dependent manner; reduces UVB-induced cytotoxicity and apoptotic nuclear fragmentation in HaCaT cells; lowers total cholesterol and triacylglycerol in 3T3-L1 adipocytes cultured under high fatty acid conditions to levels comparable to lovastatin
Cayman Chemical LIthospermIc AcId 10mg
A polyphenol; inhibits xanthine oxidase (IC50 = 5.2 UG/ml); scavenges DPPH radicals (IC50 = 23.2 UG/ml); inhibits ROS production from PMA-stimulated isolated human neutrophils in a concentration-dependent manner; inhibits 3'-processing and 3'-joining to target DNA by HIV-1 integrase (IC50s = 0.83 and 0.48 µM, respectively); inhibits acute HIV-1 infection of H9 human lymphoma cells (IC50 = 2 µM) without inducing cytotoxicity; prevents carbon tetrachloride-induced hepatic necrosis in mice at 100 mg/kg
Cayman Chemical VnP16trIfluoroACTAte salt 10mg
A synthetic peptide fragment of vitronectin; induces attachment and cell spreading of isolated human osteogenic cells when applied to cell plates at 9.1 UG/cm2; induces osteogenesis of human skin-derived mesenchymal precursors and MC3T3-E1 mouse calvarial osteoblast precursors; decreases IL-1α-induced bone loss and decreases the number of calvarial osteoclasts in mice; increases bone mineral density and decreases trabecular bone loss in a mouse model of ovariectomy-induced bone loss
Cayman Chemical Cholesterol-d6 10mg
An internal standard for the quantification of cholesterol by GC- or LC-MS
Cayman Chemical 10mthyl PalmItIc ACD mthy 10mg
A methylated fatty acid methyl ester; has been found in cyclitol-containing glycolipid analogs isolated from P. crassa
Cayman Chemical 3-HydroxyglutarIc AcId 10mg
A metabolite produced during GCDH deficiency and used as a biomarker of glutaric acidemia type 1
Cayman Chemical TIlmIcosInphosphate 10mg
A macrolide antibiotic; active against macrolide-susceptible strains of M. haemolytica, P. multocida, and E. coli (MICs = 4, 4, and 128 µM, respectively), as well as a hyperpermeable strain of E. coli (MIC = 2 µM); inhibits bacterial protein synthesis (IC50 = 0.36 µM); increases serum CK, CK-MB, and MDA levels in mice, indicating cardiotoxicity
Cayman Chemical BGJ398phosphate 10mg
A pan FGFR inhibitor (IC50s = 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively); suppresses proliferation of cancer cells with wild-type FGFR3 overexpression (IC50s = 5, 30, 32, and 15 nM, for RT112, RT4, SW780, and JMSU1 cells, respectively); inhibited tumor growth in an RT112 bladder cancer xenograft mouse model overexpressing wild-type FGFR3 at 10-30 mg/kg
Cayman Chemical 15deoxy12 14ProstaglndIn 10mg
This formulation of 15-deoxy-.DELTA.12,14-PGJ2 contains 90-95% of the trans,trans-.DELTA.12,14 isomer, and 5-10% of other double bond isomers which have similar PPARγ ligand activity (see Catalog No. 18570).
Cayman Chemical 3 3-2-Chlorophenylmethyle 10mg
An ENPP1 inhibitor (Ki = 50 µM); inhibits urease (IC50 = 84.53 µM for the Jack bean enzyme)
Cayman Chemical PrucaloprIde 10mg
A potent and selective 5-HT4 agonist (Ki = 2.5 and 8 nM for 5-HT4A and 5-HT4B, respectively); greater than 250-fold selective for 5-HT4 over a panel of 53 overexpressed receptors, including 5-HT subtypes, but does bind to human D4 and σ1 receptors and mouse 5-HT3 receptors (Kis = 2.3, 3.7, and 3.8 μM respectively); induces 5-HT4-dependent contractions in guinea pig colon (EC50 = 33 nM) and facilitates non-cholinergic contractions induced by electrical stimulation; increases colonic motility by inhibiting distal colon contractions in dogs (ED50 = 0.04 mg/kg, p.o.); increases acetylcholine and histamine levels in the rat prefrontal cortex and the power of hippocampal theta oscillations (5-10 mg/kg, s.c.)
Cayman Chemical ArachIdonyl m-NItronIlIn 10mg
A nitroaniline fatty acid amide used to measure FAAH activity; exposure to FAAH activity results in the release of the yellow colorimetric dye m-nitroaniline (ε = 13,500 at 410 nm) allowing the fast and convenient measurement of FAAH activity using a 96-well plate spectrophotometer
Cayman Chemical dIacetoxy ScIrpenol 10mg
A trichothecene mycotoxin; is toxic to pigs (LD50 = 0.38 mg/kg, i.v.); is lethal to brine shrimp (LC50 = 0.39 UG/ml); suppresses phagocytosis by, and superoxide production in, isolated microphages in an S. cerevisiae model of phagocytosis at 1 UG/ml; is toxic to barley, wheat, and sorghum seedlings (LD50s = 1.26, 3.98, and 10 mg/L, respectively); has been found as a contaminant in grasses intended to be used as animal feed